The association between growth factors and blood factors with early childhood caries

Document Type : Original Article(s)

Authors

1 Assistant Professor, Oral and Dental Diseases Research Center AND Kerman Social Determinants on Oral Health Research Center AND Department of Pediatric Dentistry, School of Dentistry, Kerman University of Medical Sciences, Kerman, Iran

2 Associate Professor, Oral and Dental Diseases Research Center AND Kerman Social Determinants on Oral Health Research Center AND Department of Oral Medicine, School of Dentistry, Kerman University of Medical Sciences, Kerman, Iran

3 Professor, Oral and Dental Diseases Research Center AND Kerman Social Determinants on Oral Health Research Center AND Department of Oral Medicine, School of Dentistry, Kerman University of Medical Sciences, Kerman, Iran

4 Professor, Research Center for Modeling in Health, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran

Abstract

BACKGROUND AND AIM: Early childhood caries (ECC) is a specific form of rampant dental caries affecting infants and young children. ECC is still a problem that threatens the health of the community and its management is important. It is believed that the majorities of children with ECC also suffer from malnutrition, anemia, low weight and altered physical growth patterns. This study was undertaken to compare blood indices [mean corpuscular volume (MCV), hemoglobin and serum ferritin] in a population of children in Kerman, Iran, and the association between growth factors, blood parameters, and ECC.METHODS: In this cross-sectional study, 240 children were selected from Afzalipour Hospital of Kerman. The subjects consisted of 2 to 6-year children, who needed blood sampling for different diagnostic reasons. Data were collected through clinical oral examinations, anthropometric measures, blood indices measurement (MCV, hemoglobin and serum ferritin) and structured questionnaire in order to assess demographic characteristics, nutritional habits and the presence or absence of systemic conditions. Data were analyzed using SPSS software.RESULTS: The mean age of subjects was 50.79 months. Of 240 children included in this study, 124 (52.1%) were girls and the rest (47.9%) were boys. Statistical test revealed that there were statically significant differences in weight as well as the height of children in experimental and control groups (P < 0.050). No significant differences were detected in the frequencies of low hematocrit levels between the groups with and without dental caries (P > 0.050).CONCLUSION: No significant association was observed between ECC and blood indices (MCV, hemoglobin and serum ferritin), but the mean height and weight in the caries-free group were significantly higher.

Keywords


  1. Casamassimo PS, Thikkurissy S, Edelstein BL, Maiorini E. Beyond the DMFT: The human and economic cost of early childhood caries. J Am Dent Assoc 2009; 140(6): 650-7.
  2. Ramos-Gomez FJ, Weintraub JA, Gansky SA, Hoover CI, Featherstone JD. Bacterial, behavioral and environmental factors associated with early childhood caries. J Clin Pediatr Dent 2002; 26(2): 165-73.
  3. Schroth RJ, Levi J, Kliewer E, Friel J, Moffatt ME. Association between iron status, iron deficiency anaemia, and severe early childhood caries: A case-control study. BMC Pediatr 2013; 13: 22.
  4. Filstrup SL, Briskie D, da Fonseca M, Lawrence L, Wandera A, Inglehart MR. Early childhood caries and quality of life: Child and parent perspectives. Pediatr Dent 2003; 25(5): 431-40.
  5. Askarizadeh N, Siyonat P. The prevalence and pattern of nursing caries in preschool children of Tehran. J Indian Soc Pedod Prev Dent 2004; 22(3): 92-5.
  6. Bargrizan M, Rahimi M, Moghadam B. Nursing caries in 2-4 years old children in Tehran. An epidemiologic survey. J Dent Sch Shahid Beheshti Univ Med Sci 2001; 18(4): 9-15. [In Persian].
  7. Poureslami H, Adhemi SH. Relationship between ECC and feeding habits among a group of babies & toddlers in Kerman. Journal of Islamic Dental Association of Iran 2001; 17: 47-55. [In Persian].
  8. Schroth RJ, Jeal NS, Kliewer E, Sellers EA. The relationship between vitamin D and severe early childhood caries: A pilot study. Int J Vitam Nutr Res 2012; 82(1): 53-62.
  9. Larson K, Russ SA, Crall JJ, Halfon N. Influence of multiple social risks on children's health. Pediatrics 2008; 121(2): 337-44.
  10. Jahanimoghadam F, Poureslami H, Shamsaddin H, Horri A, Khazaeli P, Mahvi AH. Effect of ER: Yag laser on sodium fluoride varnish uptake by primary tooth enamel: An in-vitro study. Research Report Fluoride 2016; 49(4 Pt 2): 538-48.
  11. Yusuf H, Gherunpong S, Sheiham A, Tsakos G. Validation of an English version of the Child-OIDP index, an oral health-related quality of life measure for children. Health Qual Life Outcomes 2006; 4: 38.
  12. Jahanimoghadam F, Momenidanayee S, Karimiafshar M. Correction of severe tooth rotation by using two different orthodontic appliances: Report of two cases. J Oral Health Oral Epidemiol 2016; 5(1): 46-51.
  13. Monse B, Duijster D, Sheiham A, Grijalva-Eternod CS, van Palenstein Helderman W, Hobdell MH. The effects of extraction of pulpally involved primary teeth on weight, height and BMI in underweight Filipino children. A cluster randomized clinical trial. BMC Public Health 2012; 12: 725.
  14. Greenwell AL, Johnsen D, DiSantis TA, Gerstenmaier J, Limbert N. Longitudinal evaluation of caries patterns form the primary to the mixed dentition. Pediatr Dent 1990; 12(5): 278-82.
  15. Miller J, Vaughan-Williams E, Furlong R, Harrison L. Dental caries and children's weights. J Epidemiol Community Health 1982; 36(1): 49-52.
  16. Ayhan H, Suskan E, Yildirim S. The effect of nursing or rampant caries on height, body weight and head circumference. J Clin Pediatr Dent 1996; 20(3): 209-12.
  17. Benzian H, Monse B, Heinrich-Weltzien R, Hobdell M, Mulder J, van Palenstein,Helderman W. Untreated severe dental decay: A neglected determinant of low Body Mass Index in 12-year-old Filipino children. BMC Public Health 2011; 11: 558.
  18. Ribeiro NM, Ribeiro MA. Breastfeeding and early childhood caries: A critical review. J Pediatr (Rio J) 2004; 80(5 Suppl): S199-S210.
  19. Sullivan DH. The role of nutrition in increased morbidity and mortality. Clin Geriatr Med 1995; 11(4): 661-74.
  20. Shivakumar K, Prasad S, Chandu G. International caries detection and assessment system: A new paradigm in detection of dental caries. J Conserv Dent 2009; 12(1): 10-6.
  21. Committee on Nutrition AAoP. Appendix I. Procedures for measuring growth parameters. Elk Grove Village, IL: American Academy of Pediatrics; 1998. p. 168-74
  22. Clarke M, Locker D, Berall G, Pencharz P, Kenny DJ, Judd P. Malnourishment in a population of young children with severe early childhood caries. Pediatr Dent 2006; 28(3): 254-9.
  23. Scott SP, Chen-Edinboro LP, Caulfield LE, Murray-Kolb LE. The impact of anemia on child mortality: An updated review. Nutrients 2014; 6(12): 5915-32.
  24. Jose B, King NM. Early childhood caries lesions in preschool children in Kerala, India. Pediatr Dent 2003; 25(6): 594-600.
  25. Acs G, Lodolini G, Kaminsky S, Cisneros GJ. Effect of nursing caries on body weight in a pediatric population. Pediatr Dent 1992; 14(5): 302-5.
  26. Miller J, Vaughan-Williams E, Furlong R, Harrison L. Dental caries and children's weights. J Epidemiol Community Health 1982; 36(1): 49-52.
  27. Thomas CW, Primosch RE. Changes in incremental weight and well-being of children with rampant caries following complete dental rehabilitation. Pediatr Dent 2002; 24(2): 109-13.
  28. Bagherian A, Sadeghi M. Association between dental caries and age-specific body mass index in preschool children of an Iranian population. Indian J Dent Res 2013; 24(1): 66-70.
  29. Norberg C, Hallstrom SU, Matsson L, Thorngren-Jerneck K, Klingberg G. Body mass index (BMI) and dental caries in 5-year-old children from southern Sweden. Community Dent Oral Epidemiol 2012; 40(4): 315-22.
  30. Trikaliotis A, Boka V, Kotsanos N, Karagiannis V, Hassapidou M. Short communication: Dmfs and BMI in preschool Greek children. An epidemiological study. Eur Arch Paediatr Dent 2011; 12(3): 176-8.
  31. Vazquez-Nava F, Vazquez-Rodriguez EM, Saldivar-Gonzalez AH, Lin-Ochoa D, Martinez-Perales GM,
  32. Joffre-Velazquez VM. Association between obesity and dental caries in a group of preschool children in Mexico. J Public Health Dent 2010; 70(2): 124-30.
  33. Willershausen B, Moschos D, Azrak B, Blettner M. Correlation between oral health and body mass index (BMI) in 2071 primary school pupils. Eur J Med Res 2007; 12(7): 295-9.
  34. Gaur S, Nayak R. Underweight in low socioeconomic status preschool children with severe early childhood caries. J Indian Soc Pedod Prev Dent 2011; 29(4): 305-9.
  35. Shaoul R, Gaitini L, Kharouba J, Darawshi G, Maor I, Somri M. The association of childhood iron deficiency anaemia with severe dental caries. Acta Paediatr 2012; 101(2): e76-e79.
  36. Fretham SJ, Carlson ES, Georgieff MK. The role of iron in learning and memory. Adv Nutr 2011; 2(2): 112-21.
  37. Costa LR, Daher A, Queiroz MG. Early childhood caries and body mass index in young children from low income families. Int J Environ Res Public Health 2013; 10(3): 867-78.