Evaluation of salivary immunoglobulin A level in thalassemic patients with periodontitis in comparison with thalassemic patients with healthy periodontium

Document Type: Original Article(s)


1 Assistant Professor, Oral and Dental Diseases Research Center AND Kerman Social Determinants on Oral Health Research Center AND Department of Periodontics, School of Dentistry, Kerman University of Medical Sciences, Kerman, Iran

2 Assistant Professor, Department of Periodontics, School of Dentistry, Zahedan University of Medical Sciences, Zahedan, Iran

3 Pathology and Stem Cell Research Center, Kerman University of Medical Sciences, Kerman, Iran


BACKGROUND AND AIM: This study was conducted to evaluate salivary immunoglobulin A (IgA) level in thalassemic patients with periodontitis in comparison to thalassemic patients with healthy periodontium.METHODS: Seventy-five patients were included in this study and were divided into three groups, group A: 25 major thalassemic patients with mild to moderate periodontitis, group B: 25 thalassemic patients with healthy periodontium, and group C: 25 systemically healthy people with normal periodontium. To measure salivary IgA levels, stimulated saliva was collected and analyzed by enzyme-linked immunosorbent assay (ELISA). The data were analyzed by t-test, ANOVA, and chi-square.RESULTS: Salivary IgA was significantly different in major thalassemia patients with periodontitis (69 µm/ml) in comparison to major thalassemia patients with healthy periodontium (81 µm/ml) (P < 0.05). The highest level of salivary IgA was observed in the systemically healthy people with normal periodontium (88 µm/ml).CONCLUSION: The levels of salivary IgA were decreased in major thalassemia patients with periodontitis and healthy periodontium in comparison to systemically healthy people with normal periodontium.


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