Assessment of the quality of randomized controlled trials in orthodontics published in PubMed indexed journals by Iranian authors from 2007 to 2017

Document Type: Original Article(s)


1 Orthodontist, Department of Cleft Lip and Palate, School of Dentistry AND Akbar Hospital, Mashhad University of Medical Sciences, Mashhad, Iran

2 Professor, Endodontology Research Center, Kerman University of Medical Sciences, Kerman, Iran

3 MSc Student, Department of Orthodontics, School of Dentistry, Kerman University of Medical Sciences, Kerman, Iran

4 MSc Student, Department of Periodontics, School of Dentistry, Kerman University of Medical Sciences, Kerman, Iran

5 MSc Student, Department of Bacteriology and Virology, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran


BACKGROUND AND AIM: Randomized controlled trials (RCTs) are the gold standard for providing evidence in clinical research. The present study was performed with the objective to assess the quality of reports of RCTs in orthodontics in PubMed-indexed journals published by Iranian authors from 2007 to 2017.METHODS: All the articles on orthodontics published from 2007 to 2017 and indexed in PubMed with Iran affiliations were reviewed and quality evaluation was performed on them using JADAD checklist.RESULTS: A total of 23 RCTs were evaluated. The mean of total score was 3.09 out of 5 and only 39.1% of the articles had appropriate methods of blinding and randomization. The cause for withdrawal was given in 65.2% of the articles.CONCLUSION: The results of this study indicated that the quality of RCTs published by Iranian authors in orthodontics was acceptable, however improvements were necessary.


  1. Rosenberg W, Donald A. Evidence based medicine: An approach to clinical problem-solving. BMJ 1995; 310(6987): 1122-6.
  2. Pocock SJ. Clinical trials: A practical approach. Hoboken, NJ: Wiley; 1996.
  3. Newcombe RG. Research in orthodontics-a statistical perspective. Br J Orthod 1994; 21(3): 299-302.
  4. Rinchuse DJ, Sweitzer EM, Rinchuse DJ, Rinchuse DL. Understanding science and evidence-based decision making in orthodontics. Am J Orthod Dentofacial Orthop 2005; 127(5): 618-24.
  5. Juni P, Altman DG, Egger M. Systematic reviews in health care: Assessing the quality of controlled clinical trials. BMJ 2001; 323(7303): 42-6.
  6. Jadad AR, Moore RA, Carroll D, Jenkinson C, Reynolds DJ, Gavaghan DJ, et al. Assessing the quality of reports of randomized clinical trials: Is blinding necessary? Control Clin Trials 1996; 17(1): 1-12.
  7. Begg C, Cho M, Eastwood S, Horton R, Moher D, Olkin I, et al. Improving the quality of reporting of randomized controlled trials. The CONSORT statement. JAMA 1996; 276(8): 637-9.
  8. Badri S, Akhoundi MS, Fard MJ, Momeni N, Hedayati Z, Vakili V. Orthodontic research output from iran in international and national journals. J Dent (Tehran) 2014; 11(1): 67-74.
  9. Papadopoulos MA. Meta-analyses and orthodontic evidence-based clinical practice in the 21 century. Open Dent J 2010; 4: 92-123.
  10. Pozuelo-Moyano B, Benito-Leon J, Mitchell AJ, Hernandez-Gallego J. A systematic review of randomized, double-blind, placebo-controlled trials examining the clinical efficacy of vitamin D in multiple sclerosis. Neuroepidemiology 2013; 40(3): 147-53.
  11. Sjogren P, Halling A. Quality of reporting randomised clinical trials in dental and medical research. Br Dent J 2002; 192(2): 100-3.
  12. Cioffi I, Farella M. Quality of randomised controlled trials in dentistry. Int Dent J 2011; 61(1): 37-42.
  13. Sadeghi M, Shahravan A, Haghdoost AA, Asgary S, Rad M. Trend in dental research output in Iran over a period of 20 years (1990-2009). Int Dent J 2012; 62(2): 84-9.
  14. Harrison JE. Clinical trials in orthodontics I: Demographic details of clinical trials published in three orthodontic journals between 1989 and 1998. J Orthod 2003; 30(1): 25-30.
  15. Shimada T, Takayama H, Nakamura Y. Quantity and quality assessment of randomized controlled trials on orthodontic practice in PubMed. Angle Orthod 2010; 80(4): 525-30.
  16. Habib Agahi R, Navabi N, Shahravan A, Ghassemi A. Critical appraisal of reporting randomized clinical trials published in Iranian dental journals during 2003-2010. J Dent (Tehran) 2014; 11(3): 310-8.
  17. Altman DG, Moher D, Schulz KF. Improving the reporting of randomised trials: The CONSORT Statement and beyond. Stat Med 2012; 31(25): 2985-97.
  18. Moher D, Jadad AR, Tugwell P. Assessing the quality of randomized controlled trials. Current issues and future directions. Int J Technol Assess Health Care 1996; 12(2): 195-208.