Document Type : Original Article
Associate Professor, Department of Dentomaxillofacial Radiology, Faculty of Dentistry, Bolu Abant Izzet Baysal University, Bolu, Turkey
Research Assistant, Department of Dentomaxillofacial Radiology, Faculty of Dentistry, Bolu Abant Izzet Baysal University, Bolu, Turkey
Associate Professor, Department of Periodontology, Faculty of Dentistry, Bolu Abant Izzet Baysal University, Bolu, Turkey
BACKGROUND AND AIM: The aim of this survey study was to determine the possible effects of coronavirus disease 2019 (COVID-19) on oral tissues and to investigate the relationship between changes in oral tissues and COVID-19.
METHODS: In this study, 200 volunteers who had COVID-19 in their anamnesis were included. After the routine clinical examination in the Department of Dentomaxillofacial Radiology, Faculty of Dentistry, Bolu Abant Izzet Baysal University, Bolu, Turkey, the volunteers were asked to fill out a 33-item questionnaire created on "Google Forms" to determine the changes occurred in the oral tissues during and after COVID-19. Data were analysed using descriptive statistics in SPSS software and the statistical significance level was determined using the chi-square test and McNemar’s test.
RESULTS: The study population consisted of 75 men and 125 women. While suffering from COVID-19, 53.0, 21.0, 16.0, and 17.5% of the subjects reported that they had taste loss, halitosis, pain in the chewing muscles, and pain in the temporomandibular joint (TMJ), respectively. Pain and wound in the oropharynx were the variables that more affected the possibility of halitosis (P < 0.001, Odds ratio = 4.749). Xerostomia was observed in 38.0% of the patients during the disease. In 27.6% of the patients who had xerostomia during the disease, the complaint associated with this complication continued after recovery (P < 0.001).
CONCLUSION: Xerostomia and loss of taste were the most common symptoms in the oral area during COVID-19. Further studies including clinical studies are needed to determine the relationship between changes in oral tissues and COVID-19.
- Dong E, Du H, Gardner L. An interactive web-based dashboard to track COVID-19 in real time. Lancet Infect Dis 2020; 20(5): 533-4.
- Coronaviridae Study Group of the International Committee on Taxonomy of Viruses. The species severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2. Nat Microbiol 2020; 5(4): 536-44.
- Wax RS, Christian MD. Practical recommendations for critical care and anesthesiology teams caring for novel coronavirus (2019-nCoV) patients. Can J Anaesth 2020; 67(5): 568-76.
- Andersen KG, Rambaut A, Lipkin WI, Holmes EC, Garry RF. The proximal origin of SARS-CoV-2. Nat Med 2020; 26(4): 450-2.
- Biadsee A, Biadsee A, Kassem F, Dagan O, Masarwa S, Ormianer Z. Olfactory and oral manifestations of covid-19: sex-related symptoms-a potential pathway to early diagnosis. Otolaryngol Head Neck Surg 2020; 163(4): 722-8.
- Ather A, Patel B, Ruparel NB, Diogenes A, Hargreaves KM. Coronavirus disease 19 (COVID-19): Implications for clinical dental care. J Endod 2020; 46(5): 584-95.
- Fu L, Wang B, Yuan T, Chen X, Ao Y, Fitzpatrick T, et al. Clinical characteristics of coronavirus disease 2019 (COVID-19) in China: A systematic review and meta-analysis. J Infect 2020; 80(6): 656-65.
- Sinjari B, D'Ardes D, Santilli M, Rexhepi I, D'Addazio G, Di CP, et al. SARS-CoV-2 and Oral Manifestation: An Observational, Human Study. J Clin Med 2020; 9(10).
- Wang D, Yin Y, Hu C, Liu X, Zhang X, Zhou S, et al. Clinical course and outcome of 107 patients infected with the novel coronavirus, SARS-CoV-2, discharged from two hospitals in Wuhan, China. Crit Care 2020; 24(1): 188.
- Vinayachandran D, Balasubramanian S. Is gustatory impairment the first report of an oral manifestation in COVID-19? Oral Dis 2021; 27(Suppl 3): 748-9.
- Gautier JF, Ravussin Y. A new symptom of COVID-19: Loss of taste and smell. Obesity (Silver Spring) 2020; 28(5): 848.
- Freni F, Meduri A, Gazia F, Nicastro V, Galletti C, Aragona P, et al. Symptomatology in head and neck district in coronavirus disease (COVID-19): A possible neuroinvasive action of SARS-CoV-2. Am J Otolaryngol 2020; 41(5): 102612.
- Xu H, Zhong L, Deng J, Peng J, Dan H, Zeng X, et al. High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa. Int J Oral Sci 2020; 12(1): 8.
- Saniasiaya J. Xerostomia and COVID-19: Unleashing Pandora's Box. Ear Nose Throat J 2021; 100(2_suppl): 139S.
- Bodard AGl, Deneuve S, Desoutter A. Oral manifestation of Covid-19 as an inaugural symptom? J Oral Med Oral Surg 2020; 26(2): 18.
- Martin Carreras-Presas C, Amaro SJ, Lopez-Sanchez AF, Jane-Salas E, Somacarrera Perez ML. Oral vesiculobullous lesions associated with SARS-CoV-2 infection. Oral Dis 2021; 27(Suppl 3): 710-2.
- Cruz Tapia RO, Peraza Labrador AJ, Guimaraes DM, Matos Valdez LH. Oral mucosal lesions in patients with SARS-CoV-2 infection. Report of four cases. Are they a true sign of COVID-19 disease? Spec Care Dentist 2020; 40(6): 555-60.
- Brandao TB, Gueiros LA, Melo TS, Prado-Ribeiro AC, Nesrallah ACFA, Prado GVB, et al. Oral lesions in patients with SARS-CoV-2 infection: could the oral cavity be a target organ? Oral Surg Oral Med Oral Pathol Oral Radiol 2021; 131(2): e45-e51.
- Liu L, Wei Q, Alvarez X, Wang H, Du Y, Zhu H, et al. Epithelial cells lining salivary gland ducts are early target cells of severe acute respiratory syndrome coronavirus infection in the upper respiratory tracts of rhesus macaques. J Virol 2011; 85(8): 4025-30.
- Zhou P, Yang XL, Wang XG, Hu B, Zhang L, Zhang W, et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature 2020; 579(7798): 270-3.
- Mariz BALA, Brandao TB, Ribeiro ACP, Lopes MA, Santos-Silva AR. New insights for the pathogenesis of COVID-19-related dysgeusia. J Dent Res 2020; 99(10): 1206.
- Abu-Hammad S, Dar-Odeh N, Abu-Hammad O. SARS-CoV-2 and oral ulcers: A causative agent or a predisposing factor? Oral Dis 2020.
- Ponce JB, Tjioe KC. Overlapping findings or oral manifestations in new SARS-CoV-2 infection. Oral Dis 2021; 27 Suppl 3: 781-2.
- Corsini CC, Cano CE, Assi M, Patel R, Binnicker MJ, O'Horo JC. Clinical predictors and timing of cessation of viral RNA shedding in patients with COVID-19. J Clin Virol 2020; 130: 104577.
- Lechien JR, Chiesa-Estomba CM, De Siati DR, Horoi M, Le Bon SD, Rodriguez A, et al. Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the coronavirus disease (COVID-19): A multicenter European study. Eur Arch Otorhinolaryngol 2020; 277(8): 2251-61.
- Dziedzic A, Wojtyczka R. The impact of coronavirus infectious disease 19 (COVID-19) on oral health. Oral Dis 2021; 27(Suppl 3): 703-6.
- Riad A, Kassem I, Hockova B, Badrah M, Klugar M. Halitosis in COVID-19 patients. Spec Care Dentist 2021; 41(2): 282-5.