Scoping review of the opportunities to escape oral cancer

Document Type : Review Article(s)

Author

Edinburgh Medical School: Usher Institute, University of Edinburgh, Scotland, UK

Abstract

Background: With a high rate of death and morbidity, oral cancer ranks as the sixteenth most prevalent cancer worldwide. According  to the Global Cancer Observatory (GLOBOCAN) of the International Agency for Research on Cancer (IARC), there were 177,757  oral cancer-related deaths and 377,713 new cases globally in 2020. Oral cancer in India comprises 45% of the global disease burden. Men (incidence rate: 13.1 per 100,000) are 2.62 times more likely to be affected by head and neck cancer than women (5 per 100,000) and experience double the corresponding mortality rates. The high prevalence, incidence, and excruciating nature of the disease necessitated this review to outline potential precautions and prophylactic interventions to be undertaken to prevent this agonizing and highly fatal disease in order to sensitize healthcare workers and train them to fight this disease.
Methods: The search analysis from PubMed, the World Health Organisation (WHO) International Clinical Trials Registry, Cochrane Reviews, and CENTRAL yielded a list of comprehensive strategies used in different geographic locations to prevent this deleterious health issue. 
Results: The results include evidence of interventions that have successfully prevented oral cancer in different sections of the population. In addition to controlling tobacco use and herpes virus infection, these interventions include community health programs, primary healthcare workers and dentists, chemopreventive agents, herbal extracts, and artificial intelligence models. 
Conclusion: Oral health is one factor affecting well-being, so a preventive approach must be considered to ensure its achievement. 

Keywords

Main Subjects


 1. World Health Organization (WHO). The Global Status Report
on Oral Health 2022. Available from: https://www.who.int/
team/noncommunicable-diseases/global-status-report-onoral-
health-2022.
2. Dailah HG. Mobile health (mHealth) technology in early
detection and diagnosis of oral cancer-a scoping review
of the current scenario and feasibility. J Healthc Eng.
2022;2022:4383303. doi: 10.1155/2022/4383303.
3. Rodríguez-Molinero J, Migueláñez-Medrán BDC, Puente-
Gutiérrez C, Delgado-Somolinos E, Martín Carreras-Presas
C, Fernández-Farhall J, et al. Association between oral
cancer and diet: an update. Nutrients. 2021;13(4):1299. doi:
10.3390/nu13041299.
4. Crossman T, Warburton F, Richards MA, Smith H, Ramirez
A, Forbes LJ. Role of general practice in the diagnosis of oral
cancer. Br J Oral Maxillofac Surg. 2016;54(2):208-12. doi:
10.1016/j.bjoms.2015.11.003.
5. Sari EF, Hidayat W, Dewi TS, Rezeki S, Krimadi R, McCullough
practices regarding oral potentially malignant disorders and
oral cancer in Indonesia. Clin Exp Dent Res. 2024;10(1):e807.
doi: 10.1002/cre2.807.
6. Sari M. Assessing oral cancer awareness, attitude, and
practice among Turkish dental students in 2020. J Oral
Health Oral Epidemiol. 2022;11(2):117-28. doi: 10.22122/
johoe.2022.195817.1277.
7. Sari M. Evaluation of knowledge levels of Turkish dental
students on maxillofacial trauma assessment in 2020. J Oral
Health Oral Epidemiol. 2023;12(1):27-31. doi: 10.34172/
johoe.2023.05.
8. Sharma N, Om H. Usage of probabilistic and general
regression neural network for early detection and prevention
of oral cancer. ScientificWorldJournal. 2015;2015:234191.
doi: 10.1155/2015/234191.
9. Mignogna MD, Fedele S. Oral cancer screening: 5 minutes
to save a life. Lancet. 2005;365(9475):1905-6. doi: 10.1016/
s0140-6736(05)66635-4.
10. Sankaranarayanan R, Ramadas K, Thomas G, Muwonge R,
Thara S, Mathew B, et al. Effect of screening on oral cancer
mortality in Kerala, India: a cluster-randomised controlled
trial. Lancet. 2005;365(9475):1927-33. doi: 10.1016/s0140-
6736(05)66658-5.
11. Thampi V, Hariprasad R, John A, Nethan S, Dhanasekaran
K, Kumar V, et al. Feasibility of training community
health workers in the detection of oral cancer. JAMA
Netw Open. 2022;5(1):e2144022. doi: 10.1001/
jamanetworkopen.2021.44022.
12. Kapała A, Folwarski M, Gazi A. Cross-sectional observational
study: investigation of zinc concentration in white patients
with cancer. Nutrition. 2024;117:112235. doi: 10.1016/j.
nut.2023.112235.
13. Tosti G, Pepe F, Gnagnarella P, Silvestri F, Gaeta A, Queirolo
P, et al. The role of nicotinamide as chemo-preventive agent
in NMSCs: a systematic review and meta-analysis. Nutrients.
2023;16(1):100. doi: 10.3390/nu16010100.
14. Sciubba JJ. Improving detection of precancerous and
cancerous oral lesions. Computer-assisted analysis of the
oral brush biopsy. US Collaborative OralCDx Study Group. J
Am Dent Assoc. 1999;130(10):1445-57. doi: 10.14219/jada.
archive.1999.0055.
15. Daftary DK. Temporal role of tobacco in oral carcinogenesis:
a hypothesis for the need to prioritize on precancer. Indian
J Cancer. 2010;47 Suppl 1:105-7. doi: 10.4103/0019-
509x.63863.
16. Kim SM. Human papilloma virus in oral cancer. J Korean
Assoc Oral Maxillofac Surg. 2016;42(6):327-36. doi: 10.5125/
jkaoms.2016.42.6.327.
17. Ghasemian A, Sargeran K, Khami MR, Shamshiri AR. Effects
of educational interventions based on the theory of planned
behavior on oral cancer-related knowledge and tobacco
smoking in adults: a cluster randomized controlled trial. BMC
Cancer. 2024;24(1):45. doi: 10.1186/s12885-024-11845-2.
18. Johnson NW, Warnakulasuriya S, Gupta PC, Dimba E, Chindia
M, Otoh EC, et al. Global oral health inequalities in incidence
and outcomes for oral cancer: causes and solutions. Adv Dent
Res. 2011;23(2):237-46. doi: 10.1177/0022034511402082.
19. Peter TK, Withanage MH, Comnick CL, Pendleton C,
Dabdoub S, Ganesan S, et al. Systematic review and metaanalysis
of oral squamous cell carcinoma associated oral
microbiome. Front Microbiol. 2022;13:968304. doi: 10.3389/
fmicb.2022.968304.
20. de Lima Saintrain MV, Bandeira AB, Pequeno LL, Bizerril
DO, Marques PL, Viana FA. Oral health of older people:
tracking soft tissue injuries for the prevention of oral cancer.
Rev Esc Enferm USP. 2018;52:e03380. doi: 10.1590/s1980-
220x2017033603380.
21. Rao CV. Immunomodulatory effects of Momordica charantia
extract in the prevention of oral cancer. Cancer Prev Res
(Phila). 2018;11(4):185-6. doi: 10.1158/1940-6207.Capr-17-
0379.
22. Wang WC, Chen CY, Hsu HK, Lin LM, Chen YK.
Chemopreventive effect of Toona sinensis leaf extract on
7,12-dimethylbenz[a]anthracene-induced hamster buccal
pouch squamous cell carcinogenesis. Arch Oral Biol.
2016;70:130-42. doi: 10.1016/j.archoralbio.2016.06.015.
23. Mignogna MD, Fedele S, Ruoppo E, Lo Russo L. The role
of molecular techniques in preventing oral cancer and
improving its poor prognosis: an illusion? J Oral Pathol Med.
2002;31(4):246-8. doi: 10.1034/j.1600-0714.2002.310411.x.
24. Yardimci G, Kutlubay Z, Engin B, Tuzun Y. Precancerous
lesions of oral mucosa. World J Clin Cases. 2014;2(12):866-
72. doi: 10.12998/wjcc.v2.i12.866.
25. Ministry of Health and Family Welfare, Government of India.
Global Adult Tobacco Survey: India 2016-17 Report. Available
from: https://ntcp.mohfw.gov.in/assets/document/surveysreports-
publications/Global-Adult-Tobacco-Survey-Second-
Round-India-2016-2017.pdf.
26. William WN Jr, Papadimitrakopoulou V, Lee JJ, Mao L, Cohen
EE, Lin HY, et al. Erlotinib and the risk of oral cancer: the
erlotinib prevention of oral cancer (EPOC) randomized
clinical trial. JAMA Oncol. 2016;2(2):209-16. doi: 10.1001/
jamaoncol.2015.4364.
27. Chiang SL, Velmurugan BK, Chung CM, Lin SH, Wang ZH,
Hua CH, et al. Preventive effect of celecoxib use against
cancer progression and occurrence of oral squamous cell
carcinoma. Sci Rep. 2017;7(1):6235. doi: 10.1038/s41598-
017-06673-3.
28. A Phase IIb Cancer Prevention Trial of Celecoxib, a Selective
COX-2 Inhibitor, in Oral Leukoplakia [Internet]. 2005.
Available from: https://clinicaltrials.gov/study/NCT00101335.
29. Ehtesham H, Safdari R, Mansourian A, Tahmasebian S,
Mohammadzadeh N, Ghazisaeedi M, et al. Clinical decision
support system, a potential solution for diagnostic accuracy
improvement in oral squamous cell carcinoma: a systematic
review. J Oral Health Oral Epidemiol. 2017;6(4):187-95.
30. Jackson JS, Rondeau B. Mallampati score. In: StatPearls
[Internet]. Treasure Island, FL: StatPearls Publishing; 2025.
Available from: https://www.ncbi.nlm.nih.gov/books/
NBK585119/.