Journal of Oral Health and Oral Epidemiology

Journal of Oral Health and Oral Epidemiology

Association of helicobacter pylori and oral lichen planus: A systematic review and meta-analysis

Document Type : Review Article(s)

Authors
Solmaz Pourzare-Mehrbani 1
Paria Motahari 1
Fatemeh Pournaghi-Azar 2
Pouya Alizadeh 3
Fatemeh Salehnia 4
1 Assistant Professor, Department of Oral Medicine, School of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran
2 Assistant Professor, Department of Restorative Dentistry, School of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran
3 Student of Dentistry, Department of Oral Medicine, School of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran
4 Liver and Gastrointestinal Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
10.22122/johoe.v10i1.1132
Abstract
BACKGROUND AND AIM: Oral lichen planus (OLP) has been known as an inflammatory disease and might have an association with helicobacter pylori (H. pylori) infection. The main purpose of this study is to evaluate the role of H. pylori in patients with OLP.
METHODS: In this review study, all articles with English abstracts were searched in the Google Scholar, PubMed, Web of Science, Cochrane Library, and Scopus databases up to May 2020. The searches were performed using the Medical Subject Headings (MeSH) terms and keywords of "oral lichen planus" or "oral lichenoid reaction" or "OLP" and "Helicobacter pylori" or "H. pylori". The heterogeneity percentage obtained during different studies was evaluated by the Cochrane (Q) test and I2 statistic. The analyses were performed by the Comprehensive Meta-Analysis (CMA) software version 2.0.
RESULTS: Amongst the 16 articles obtained after the abstract review, 7 proper articles fitted to our study were included in this meta-analysis. The meta-analysis results showed that the incidence of H. pylori in patients with OLP was 2.9 times greater than that in the control group (P < 0.05).
CONCLUSION: Based on the results of previous studies, H. pylori increases the risk of OLP lesions. Therefore, testing for H. pylori infection in these patients before starting routine treatment is recommended.
Keywords
Lichen Planus
Oral
Helicobacter Pylori
Meta-Analysis
  1. Greenberg MS, Glick M. Burket's Oral Medicine: Diagnosis and Treatment. 12th ed. Hamilton, ON: Bc Decker; 2015. p. 104.
  2. Hasan S, Ahmed S, Kiran R, Panigrahi R, Thachil JM, Saeed S. Oral lichen planus and associated comorbidities: An approach to holistic health. J Family Med Prim Care 2019; 8(11): 3504-17.
  3. Zucoloto ML, Shibakura MEW, Pavanin JV, Garcia FT, da Silva Santos PS, Maciel AP, et al. Severity of oral lichen planus and oral lichenoid lesions is associated with anxiety. Clin Oral Investig 2019; 23(12): 4441-8.
  4. Mehrbani SP, Motahari P, Azar FP, Ahari MA. Role of interleukin-4 in pathogenesis of oral lichen planus: A systematic review. Med Oral Patol Oral Cir Bucal 2020; 25(3): e410-e415.
  5. MotahariP, Pournaghi Azar F, Rasouly P. Association of interferon-gamma gene polymorphism (+874 A/T) and oral lichen planus susceptibility: Systematic review and meta-analysis. Jorjani Biomedicine Journal 2019; 7(3): 45-55.
  6. Motahari P, Pournaghi Azar F, Rasi A. Role of vitamin D and vitamin D receptor in oral lichen planus: A systematic review. Ethiop J Health Sci 2020; 30(4): 615-22.
  7. Sanli H, Cetinkaya H, Tursen U, Kaya M, Kuzu I, Gurler A. Upper gastrointestinal findings in oral lichen planus. Turk J Gastroenterol 2002; 13(1): 31-4.
  8. Brown LM. Helicobacter pylori: Epidemiology and routes of transmission. Epidemiol Rev 2000; 22(2): 283-97.
  9. Blaser MJ. Who are we? Indigenous microbes and the ecology of human diseases. EMBO Rep 2006; 7(10): 956-60.
  10. Liu H, Merrell DS, Semino-Mora C, Goldman M, Rahman A, Mog S, et al. Diet synergistically affects helicobacter pylori-induced gastric carcinogenesis in nonhuman primates. Gastroenterology 2009; 137(4): 1367-79.
  11. Riggio MP, Lennon A, Wray D. Detection of Helicobacter pylori DNA in recurrent aphthous stomatitis tissue by PCR. J Oral Pathol Med 2000; 29(10): 507-13.
  12. Ryu J, Seungwoo K, Yoon CL, Ahn JM. Detection of Helicobacter pylori in Saliva of Patient with Oral Lichen Planus. Journal of Oral Medicine 2008; 33(3): 241-6.
  13. Khan Sherwani S, Abidi SH, Rasheed F, Alam J, Shoaib M, Kazmi S. Relationship between Lichen Planus and Helicobacter pylori positive patients in Karachi- Pakistan. Eur Acad Res 2013; 1(6): 1509-17.
  14. Kazanowska-Dygdala M, Dus I, Radwan-Oczko M. The presence of Helicobacter pylori in oral cavities of patients with leukoplakia and oral lichen planus. J Appl Oral Sci 2016; 24(1): 18-23.
  15. Irani S, Monsef EA, Bidari ZF. Detection of Helicobacter pylori in oral lesions. J Dent Res Dent Clin Dent Prospects 2013; 7(4): 230-7.
  16. Taghavi ZA, Mehdipour M, Jafari HM, Gholizadeh N. Relationship between lichen planus and Helicobacter pylori Infection. J Dent Res Dent Clin Dent Prospects 2010; 4(1): 17-20.
  17. Hulimavu SR, Mohanty L, Tondikulam NV, Shenoy S, Jamadar S, Bhadranna A. No evidence for Helicobacter pylori in oral lichen planus. J Oral Pathol Med 2014; 43(8): 576-8.
  18. Mravak-Stipetic M, Gall-Troselj K, Lukac J, Kusic Z, Pavelic K, Pavelic J. Detection of Helicobacter pylori in various oral lesions by nested polymerase chain reaction (PCR). J Oral Pathol Med 1998; 27(1): 1-3.
  19. Yangyang SH, Yizhou L, Xiaoling N. Correlation between oral Helicobacter pylori infection and oral lichen planus: A systematic review. International Journal of Laboratory Medicine 2017; 38(24): 3365-7.
  20. Moher D, Liberati A, Tetzlaff J, Altman DG. Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement. PLoS Med 2009; 6(7): e1000097.
  21. Boudin F, Nie JY, Bartlett JC, Grad R, Pluye P, Dawes M. Combining classifiers for robust PICO element detection. BMC Med Inform Decis Mak 2010; 10: 29.
  22. Stang A. Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol 2010; 25(9): 603-5.
  23. Pourshahidi S, Fakhri F, Ebrahimi H, Fakhraei B, Alipour A, Ghapanchi J, et al. Lack of association between Helicobacter pylori infection and oral lichen planus. Asian Pac J Cancer Prev 2012; 13(5): 1745-7.
  24. Lopes AI, Vale FF, Oleastro M. Helicobacter pylori infection - recent developments in diagnosis. World J Gastroenterol 2014; 20(28): 9299-313.
  25. Patel SK, Pratap CB, Jain AK, Gulati AK, Nath G. Diagnosis of Helicobacter pylori: what should be the gold standard? World J Gastroenterol 2014; 20(36): 12847-59.
  26. Tchernev G, Nenoff P. Antigen mimicry followed by epitope spreading: A pathogenetic trigger for the clinical morphology of lichen planus and its transition to Graham Lassueur Piccardi Little Syndrome and keratosis lichenoides chronica - Medical hypotheses or reality? An Bras Dermatol 2009; 84(6): 682-8.
  27. Mignogna MD, Lo RL, Fedele S. Gingival involvement of oral lichen planus in a series of 700 patients. J Clin Periodontol 2005; 32(10): 1029-33.
  28. Stone SJ, Heasman PA, Staines KS, McCracken GI. The impact of structured plaque control for patients with gingival manifestations of oral lichen planus: A randomized controlled study. J Clin Periodontol 2015; 42(4): 356-62.
Journal of Oral Health and Oral Epidemiology
Volume 10, Issue 1
Winter 2021
Pages 1-6

  • Receive Date 17 June 2020
  • Revise Date 15 September 2020
  • Accept Date 19 September 2020