Journal of Oral Health and Oral Epidemiology

Journal of Oral Health and Oral Epidemiology

A Case Report of a Huge Nerve Sheath Myxoma of the Anterior Gingiva in a 47-Year-Old Lady: Diagnostic Confirmation with Immunohistochemical Analysis

Document Type : Case Report(s)

Authors
Manas Bajpai 1
Deepak Singh 2
Saurabh L Sabnis 1
Vandana Pandey Tripathi 3
1 Department of Oral Pathology & Microbiology, Rural Dental College, Pravara Institute of Medical Sciences (PIMS-DU) Loni, Maharashtra, India
2 Department of Oral and Maxillofacial Surgery, Rural Dental College, Pravara Institute of Medical Sciences (PIMS-DU) Loni, Maharashtra, India
3 Department of Pedodontics and Preventive Dentistry, Government Dental College, Mumbai, India
10.34172/johoe.1752
Abstract
Background: Nerve sheath myxoma (NSM) is a rare, benign soft tissue neoplasm arising from peripheral nerves. It typically presents as a slow-growing, painless mass, often in the extremities. Intraoral NSMs are exceedingly rare, and large lesions involving the gingiva are even less common.
Case Presentation: This case report describes a 47-year-old female who presented with a large, exophytic, painless mass involving the anterior gingiva. The lesion was surgically excised, and histopathological examination, together with immunohistochemical staining for S-100, EMA, Calponin, and SOX-10, confirmed the diagnosis of nerve sheath myxoma.
Conclusion: This report highlights the rarity of NSM, its diagnostic challenges, and the importance of immunohistochemistry for accurate diagnosis, particularly at unusual intraoral sites.
Keywords
Nerve sheath myxoma
S-100 protein
Neurothekeoma
Calponins
Immunohistochemistry
Subjects
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Journal of Oral Health and Oral Epidemiology
Volume 15
Pages 1-5

  • Receive Date 06 June 2025
  • Revise Date 04 August 2026
  • Accept Date 08 August 2026